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Because of these limitations, any discussion of combined use should be understood as experimental, with key questions still unanswered regarding long-term safety, comparative effectiveness, pharmacokinetics, and systemic impact

Ubiquitination analysis revealed that ETV6 was primarily modified by K48-linked ubiquitin chains, which serve as a canonical signal for proteasomal degradation (Fig

On the other hand, these conjugations also play an essential role in the toxicity of many chemicals due to the metabolic formation of toxic metabolites such as reactive electrophiles

Prostaglandins other Lipid Mediators (2019) 144:106363